Avène Retrinal Cream .05If you are new to retinoids, this is the perfect place to start! Avne Retinal 0. 05 Cream corrects and prevents the signs of aging with a patented mixture of refining and retexturizing ingredients. This paraben and fragrance free formula utilizes a high concentration of Avne Thermal Spring Water, retinaldehyde and relastide peptides to smooth away fine lines and fill in wrinkles for a more youthful appearance. Skin is more toned, fuller and firmer.