How long until I notice a difference? That's one of the most common questions we hear about phentermine, a medication used to help people with obesity jumpstart weight loss. And the answer First Weight Gain since starting. I had to use phentermine because I'm on a very low calorie diet. Phentermine loses its affect after a while and I think it's what's happening to GLP 1 vs GLP 1 GIP: What's the Difference? You've probably heard about Semaglutide and Tirzepatide two popular options for medical weight loss but what actually sets them apart? Semaglutide ( Hormone therapy supercharges weight loss for postmenopausal women, Mayo Clinic study finds Medicare will negotiate Novo's GLP 1 drug price. Here's what that means for Ozempic, Wegovy. BioPharma Dive